Template for Extended Abstract contributions to INDOOR AIR 2022

This investigation presents results of Computational Fluid Dynamics (CFD) modelling of aerosol behaviour within an arbitrary 'realistic' 100m2 office environment, with dynamic and variable respiratory droplet release profile applied based on published findings (Morawska et al., 2009). A multitude of ventilation strategies and configurations have been applied to the base model to compare the effectiveness of reducing the concentration of suspended aerosols over time. A key finding of the investigation indicates a relatively low sensitivity to increasing outside air percentage, and that the benefit from this strategy is heavily dependent on the in-duct droplet decay factor. The application of local recirculating air filtration systems with MERV-13 filters mounted on occupant desks proved significantly more effectiveness than increasing outside air concentration from 25% to 100% in reducing the quantity of suspended aerosols. This highlights that the ventilation industry should perhaps focus on opportunities to integrate filtration systems into furniture, partitions, cabinetry etc., and that an appliance-based solution may be more beneficial for reducing COVID-19 transmission in buildings (and likely more straightforward) than modifications to central ventilation systems, particularly in the application of refurbishments and retrofits. © 2022 17th International Conference on Indoor Air Quality and Climate, INDOOR AIR 2022. All rights reserved.

Detection and isolation of airborne SARS-CoV-2 in a hospital setting.

Transmission mechanisms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. In particular, aerosol transmission remains unclear, with viral detection in air and demonstration of its infection potential being actively investigated. To this end, we employed a novel electrostatic collector to sample air from rooms occupied by COVID-19 patients in a major Swedish hospital. Electrostatic air sampling in conjunction with extraction-free, reverse-transcriptase polymerase chain reaction (hid-RT-PCR) enabled detection of SARS-CoV-2 in air from patient rooms (9/22; 41%) and adjoining anterooms (10/22; 45%). Detection with hid-RT-PCR was concomitant with viral RNA presence on the surface of exhaust ventilation channels in patients and anterooms more than 2 m from the COVID-19 patient. Importantly, it was possible to detect active SARS-CoV-2 particles from room air, with a total of 496 plaque-forming units (PFUs) being isolated, establishing the presence of infectious, airborne SARS-CoV-2 in rooms occupied by COVID-19 patients. Our results support circulation of SARS-CoV-2 via aerosols and urge the revision of existing infection control frameworks to include airborne transmission.

Control of airborne infectious disease in buildings: Evidence and research priorities.

The evolution of SARS-CoV-2 virus has resulted in variants likely to be more readily transmitted through respiratory aerosols, underscoring the increased potential for indoor environmental controls to mitigate risk. Use of tight-fitting face masks to trap infectious aerosol in exhaled breath and reduce inhalation exposure to contaminated air is of critical importance for disease control. Administrative controls including the regulation of occupancy and interpersonal spacing are also important, while presenting social and economic challenges. Indoor engineering controls including ventilation, exhaust, air flow control, filtration, and disinfection by germicidal ultraviolet irradiation can reduce reliance on stringent occupancy restrictions. However, the effects of controls-individually and in combination-on reducing infectious aerosol transfer indoors remain to be clearly characterized to the extent needed to support widespread implementation by building operators. We review aerobiologic and epidemiologic evidence of indoor environmental controls against transmission and present a quantitative aerosol transfer scenario illustrating relative differences in exposure at close-interactive, room, and building scales. We identify an overarching need for investment to implement building controls and evaluate their effectiveness on infection in well-characterized and real-world settings, supported by specific, methodological advances. Improved understanding of engineering control effectiveness guides implementation at scale while considering occupant comfort, operational challenges, and energy costs.